Methods for Manufacturing a Polyclonal Protein
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United States of America Patent
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Issued Date -
May 19, 2011
app pub date -
Apr 23, 2009
filing date -
Apr 23, 2008
priority date (Note) -
Abandoned
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Abstract
The invention relates to methods for manufacturing drug products comprising at least two distinct members of a polyclonal protein, for example a polyclonal antibody, where each distinct member is expressed by a separate population of cells. The methods involve at least an initial step in which the cell populations expressing the distinct members of the polyclonal protein are cultured separately. The individual cell populations, or proteins expressed by the individual cell populations, are combined at a later point of the upstream or downstream processing to result in a single drug product comprising the distinct members of the polyclonal protein.
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