HUMAN ANTIBODY CAPABLE OF INDUCING APOPTOSIS
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United States of America Patent
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Issued Date -
May 19, 2011
app pub date -
Nov 18, 2008
filing date -
Nov 19, 2007
priority date (Note) -
Abandoned
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Abstract
A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases.
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