COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS

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United States of America Patent

APP PUB NO 20110117125A1
SERIAL NO

12811195

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

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Patent Owner(s)

Patent OwnerAddress
ARBUTUS BIOPHARMA CORPORATION100-8900 GLENLYON PARKWAY BURNABY BRITISH COLUMBIA V5J 5J8

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Jianxin Vancouver, CA 60 1393
Ciufolini, Marco A Vancouver, CA 23 625
Cullis, Pieter R Vancouver, CA 82 6269
Hope, Michael J Vancouver, CA 56 3601
Kallanthottathil, Rajeev G Wayland, US 2 73
Madden, Thomas D Vancouver, CA 41 2383
Manoharan, Muthiah Weston, US 491 18658
Mui, Barbara Vancouver, CA 18 645
Semple, Sean C Delta, CA 25 1387
Wong, Kim F Vancouver, CA 11 420

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