THERAPEUTIC AGENTS AND TARGETS
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United States of America Patent
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Issued Date -
May 12, 2011
app pub date -
May 17, 2006
filing date -
May 17, 2005
priority date (Note) -
Abandoned
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Abstract
The present invention relates to diagnostic and therapeutic methods in relation to diabetic complications, such as blindness, nephropathy and cardiovascular disease, and inflammatory conditions, such as angina, arthritis, empyema pharyngitis and urinary tract infection. Diagnostic methods involve screening for up regulated expression of decor (Den) or thioredoxin-like protein 19 (TLP 19). Therapeutic methods involve modulation of expression or activity o Den or TLP 19. The invention also relates to screening methods for identifying functional signal sequences to screen for secreted, membrane-bound and exported proteins and cell surface receptors.
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