COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

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United States of America Patent

APP PUB NO 20110112127A1
SERIAL NO

12939998

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Abstract

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Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.

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Patent Owner(s)

Patent OwnerAddress
PLEXXIKON INC91 BOLIVAR DRIVE SUITE A BERKELEY CA 94710

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bremer, Ryan Oakland, US 31 2356
Cho, Hanna Oakland, US 37 2542
Ibrahim, Prabha N Mountain View, US 139 6723
Spevak, Wayne Berkeley, US 81 3774
Zhang, Jiazhong Foster City, US 81 4102

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