Poly(ADP-ribose) polymerase genes
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United States of America Patent
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Jun 9, 2015
Grant Date -
May 5, 2011
app pub date -
May 12, 2010
filing date -
Jun 5, 1998
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Abstract
The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has
- a) a functional NAD binding domain andb) no zinc finger sequence motif of the general formulaCX2CXmHX2C in whichm is an integral value from 28 or 30, and the X radicals are, independently of one another, any amino acid;and the functional equivalents thereof; nucleic acids coding therefor; antibodies with specificity for the novel protein; pharmaceutical and gene therapy compositions which comprise products according to the invention; methods for the analytical determination of the proteins and nucleic acids according to the invention; methods for identifying effectors or binding partners of the proteins according to the invention; novel PARP effectors; and methods for determining the activity of such effectors.
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