METHOD OF SYNTHESIZING SEVOFLURANE
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United States of America Patent
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Issued Date -
May 5, 2011
app pub date -
Jul 2, 2009
filing date -
Jul 2, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method of synthesizing sevoflurane, which comprises the following steps: taking hexafluoro isopropanol as the starting material and reacting it with trioxymethylene (or paraformaldehyde) in the presence of acid to generate dihexafluoro isopropanol formal derivatives, adding anhydrous aluminum trihalide to generate halomethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether, then reacting the halomethyl compound with metal fluoride to form the sevoflurane. The method is of low cost, and the reaction condition is easy to implement, and produces sevoflurane in large scale.
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