Small molecule inhibitors of PARP activity
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United States of America Patent
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app pub date -
Nov 19, 2009
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Oct 22, 2008
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Abstract
Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such componds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
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