PRODUCTION OF GLUCAGON LIKE PEPTIDE 2 AND ANALOGS
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United States of America Patent
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Sep 30, 2010
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Nov 21, 2003
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Abstract
GLP-2 peptides and analogs thereof are produced in high yield and with desired, authentic termini by isolation from a GLP-2 peptide multimer in which at least two units of GLP-2 peptide are coupled through a linker that presents an N-terminal acid cleavage site and a C-terminal enzyme cleavage site. In a specific embodiment, [Gly.sup.2]hGLP-2 is produced from a multimeric precursor comprising 2-30 units thereof.
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