ASSESSMENT OF EFFECT OF AN AGENT ON A HUMAN BIOLOGICAL CONDITION USING RODENT GENE EXPRESSION PANELS
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United States of America Patent
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app pub date -
Jul 29, 2010
filing date -
May 16, 2006
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Abandoned
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Abstract
Rodent gene expression data, in particular, gene expression profiles, are created and used to predict the efficacy of therapeutic agents on human biological conditions. Gene Profile data sets are derived from rodent subject samples and include quantitative, substantially repeatable measures of a distinct amount of RNA or protein constituent(s) in a signature panel selected such that measurement of the constituent(s) enables measurement of a biological condition of interest in both human and rodent subjects. Such profile data sets may be used to predict the therapeutic efficacy of a therapeutic agent in humans.
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