Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels
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United States of America Patent
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Issued Date -
Apr 21, 2011
app pub date -
Mar 16, 2010
filing date -
Oct 16, 2009
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Abstract
Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.
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