Oral Solid Solution Formulation of a Poorly Water-Soluble Active Substance
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United States of America Patent
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app pub date -
Nov 12, 2010
filing date -
Feb 14, 2002
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Abstract
An immediate release pharmaceutical formulation of a poorly water-soluble biologically active substance with enhanced bio-availability, the formulation being a homogeneous and thermostable solid solution, and the solid solution including as percentages of the total weight of the formulation: a) 10 to 50% of the active substance; b) 20 to 70% of a non-ionic hydrophilic surfactant which is liquid between 15 and 30.degree. C.; c) 5 to 70% of a pharmaceutically acceptable organic polymer or polymer mixture which is liquid above 60.degree. C. and solid below 30.degree. C., and d) optionally, 1 to 10% of a disintegrating agent; as well as active substances formulated into such form, and methods for producing such formulations.
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