HISTONE OCTAMERS FOR INCREASED NUCLEIC ACID TRANSFER
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United States of America Patent
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Issued Date -
Apr 7, 2011
app pub date -
Sep 22, 2010
filing date -
Oct 1, 2009
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Abstract
The present invention provides reconstituted histone octamers with multiple modifications (e.g. acetylation of all histones and trimethylation of histone H3K4) assembled onto plasmids for increased transcription post-transfection using our unique bi-lamellar invaginated liposomes (BIVs) to more effectively recruit the transcriptional machinery of human cancer cells post-transfection and substantially increase the production of therapeutic gene products.
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