MATERIALS AND METHODS RELATING TO A G-PROTEIN COUPLED RECEPTOR

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United States of America Patent

APP PUB NO 20110076274A1
SERIAL NO

12992312

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present inventors demonstrate that the G-protein coupled receptor 55 (GPR55) is highly expressed in human aggressive breast cancer cells, and that the expression level may be correlated with the invasiveness and metastatic potential of these cells (for example metastasis to bone). In various aspects of the invention there are disclosed diagnostic tools or biomarkers that relate to the metastatic profile of breast cancer tumours. The invention also relates to pharmacological agents targeting this receptor for the purposes of inhibiting progression and spread of breast cancer.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEENKING'S COLLEGE ABERDEEN AB24 3FX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ford, Lesley Ann Aberdeen, Scotland, GB 4 70
Roelofs, Anke Jozefien Aberdeen, Scotland, GB 1 0
Rogers, Michael John Aberdeen, Scotland, GB 2 5
Ross, Ruth Alexandra Aberdeen, Scotland, GB 7 103

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