Utilization of Pharmacological Chaperones to Improve Manufacturing and Purification of Biologics
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United States of America Patent
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Issued Date -
Mar 24, 2011
app pub date -
May 26, 2010
filing date -
May 26, 2009
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Abstract
The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell.
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