Yeast Biocatalysts for Degradation of Biowarfare Agents
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United States of America Patent
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Issued Date -
Mar 10, 2011
app pub date -
Jan 7, 2008
filing date -
Jan 9, 2007
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Abstract
. A phage lysin may be selected from the group consisting of PlyG and PlyPH. A method of detoxifying a biowarfare agent may include contacting a biowarfare agent with a yeast biocatalyst under conditions that permit detoxification. Conditions that permit detoxification, according to some embodiments, may include conditions that permit expression and secretion of a phage lysin. In some embodiments, conditions that permit detoxification may include conditions that permit germination of a spore. For example, a method of detoxifying a biowarfare agent spore may include contacting the spore with growth media (e.g., complete media or complex media) having alanine.
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