METHOD OF TREATMENT AND AGENTS USEFUL FOR SAME
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United States of America Patent
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Issued Date -
Mar 3, 2011
app pub date -
Oct 5, 2007
filing date -
Oct 6, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention relates generally to a method of modulating tumor necrosis factor-mediated apoptosis and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated hepatocyte apoptosis by modulating an intracellular Bim and/or Bid-dependent signalling mechanism. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by aberrant, unwanted or otherwise inappropriate tumor necrosis factor-mediated apoptosis. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject Bim and/or Bid-dependent signalling mechanism.
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