USE OF PDE5 INHIBITORS FOR TREATING CIRCADIAN RHYTHM DISORDERS
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United States of America Patent
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Issued Date -
Feb 24, 2011
app pub date -
May 29, 2008
filing date -
Sep 5, 2007
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Abandoned
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Abstract
A method of altering circadian rhythm in a mammal is provided. In certain embodiments, the method comprising: administering to the mammal a PDE5 inhibitor, e.g., sildenafil, vardenafil, tadalafil or zaprinast. The method may be employed to prevent a circadian rhythm disorders including, but not limited to transmeridian flight disorder (i.e., “jet-lag”), shiftwork-related disorder, seasonal affected disorder and insomnia by phase delay or phase advance.
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