NON-HUMAN MAMMAL MODEL OF EPILEPSY
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United States of America Patent
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Issued Date -
Feb 17, 2011
app pub date -
Feb 10, 2009
filing date -
Feb 12, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention provides a genuine epilepsy model animal as an improvement over conventional epilepsy model animals which are socalled seizures model animals mainly causing seizure attacks to be forcibly induced. Also provided is a method that allows for easy identification of the recombinants.The model non-human mammalian animal for human epilepsy according to the present invention is a human epilepsy model non-human mammalian animal, such as a rat model, that has the same genetic defects as those in human epilepsy. The model non-human mammalian animal has a mutated gene obtained by introducing a genetic mutation to the non-human mammalian DNA of the α4 subunit (CHRNA4) or β2 subunit (CHRNB2) of the neuronal nicotinic acetylcholinergic receptor gene associated with human autosomal dominant nocturnal frontal lobe epilepsy, and by introducing a specific probe. The human epilepsy model non-human mammalian animal of the present invention allows for easy identification of the recombinants.
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