Mosaic knockout mouse tumor models and methods or use
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United States of America Patent
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Issued Date -
Feb 10, 2011
app pub date -
Aug 9, 2010
filing date -
Aug 10, 2009
priority date (Note) -
Abandoned
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Abstract
Disclosed herein are transgenic mouse tumor models. A portion of the cells of the disclosed transgenic mice undergo directed somatic recombination and the mouse is therefore a mosaic for homozygous knockout of p53, NF1, or both p53 and NF1 genes. The homozygous null cells resulting from the somatic recombination also express a detectable fluorescent protein, and the resulting sibling cells, which are wild type for p53, NF1, or both p53 and NF1, express a different detectable fluorescent protein. Also disclosed herein are methods of identifying compounds for treating or preventing a tumor, using the disclosed transgenic mice.
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