14-3-3 Antagonists for the Prevention and Treatment of Arthritis
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United States of America Patent
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Issued Date -
Feb 3, 2011
app pub date -
Nov 26, 2008
filing date -
Nov 27, 2007
priority date (Note) -
Abandoned
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Abstract
Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14-3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical composition and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3.
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