Sugar Chain-Related Gene and Use Thereof
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United States of America Patent
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Issued Date -
Feb 3, 2011
app pub date -
Dec 26, 2008
filing date -
Dec 27, 2007
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Abstract
As a result of dedicated studies, the present inventors succeeded in discovering, for the first time, that fibrogenesis could be suppressed at the physiological tissue level by inhibiting sulfation at position 4 or 6 of GalNAc, which is a sugar that constitutes sugar chains. Furthermore, the present inventors conducted studies using various disease model animals, and as a result, successfully demonstrated that inhibitors of sulfation at position 4 or 6 of GalNAc had therapeutic effects on diseases caused by tissue fibrogenesis (tissue fibrogenic disorders).
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