Screening method for damaged DNA repairing substance
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United States of America Patent
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Issued Date -
Jan 27, 2011
app pub date -
Jan 28, 2010
filing date -
Jul 23, 2009
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Abandoned
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Abstract
H-thymidine and BrdU or recovery of RNA synthesis (RRS) test, and the like. By measuring UDS activity quickly at high sensitivity using a method of nucleotide fluorescence detection with the use of a click chemistry reaction (e.g., detection of terminal alkyne-modified nucleoside by means of a reporter molecule containing an azide moiety), a substance capable of DNA repair can be selected.
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