Novel mRNA splice variant of the doublecortin-like kinase gene and its use in cancer diagnosis and therapy

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United States of America Patent

SERIAL NO

12785852

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Abstract

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Methods for treating neuroblastoma in a subject are provided. The methods include administering to the subject nucleic acid that is capable of causing a significant reduction of the amount of doublecortin like protein (DCL) in the subject. The nucleic acids include antisense oligonucleotides and small interfering RNA.

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Patent Owner(s)

Patent OwnerAddress
PROSENSA HOLDING B VJ H OORTWEG 21 LEIDEN 2333 CH

International Classification(s)

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  • 2010 Application Filing Year
  • A61K Class
  • 10962 Applications Filed
  • 7633 Patents Issued To-Date
  • 69.64 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Van, Kuik-Romeijn Petra Utrecht, NL 4 37
VREUGDENHIL, Erno Leiden, NL 3 0

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  • A61K Class
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  • 14 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges7424023113748323813073422412123001 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +025050075010001250150017502000225025002750300032503500375040004250

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