BENDAMUSTINE AMPHIPHILIC CATIONIC COMPOSITIONS
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United States of America Patent
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Issued Date -
Jan 20, 2011
app pub date -
Jul 19, 2010
filing date -
Jul 20, 2009
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Abandoned
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Abstract
The present invention is directed to pharmaceutical compositions comprising bendamustine and one or more amphiphilic cationic compounds, which self assemble to form aggregates. The exhibiting enhanced stability in aqueous solutions, including plasma. The unexpectedly enhanced stability afforded by such aggregates permits patients to be treated with bendamustine in lower and/or with less frequent dosages or to improve its therapeutic effect while using the same as presently used treatment protocol.
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