POLYPEPTIDE HAVING GLYOXALASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF
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United States of America Patent
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Issued Date -
Jan 20, 2011
app pub date -
Mar 16, 2009
filing date -
Mar 18, 2008
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Abandoned
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Abstract
The present invention relates to a novel polypeptide having the enzymatic activity of conversion of methylglyoxal to lactic acid in a single step (known as glyoxalase III activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof.The invention relates to the modulation of the glyoxalase III activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide.The invention also relates to the production of commodity chemicals, especially 1,2-propanediol, acetol, and lactic acid by fermenting microorganisms wherein their glyoxalase III activity is modulated.
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