HUMANIZED ANTI-HUMAN ALPHA 9-INTEGRIN ANTIBODY

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United States of America Patent

APP PUB NO 20110014193A1
SERIAL NO

12812368

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Abstract

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The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.

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Patent Owner(s)

Patent OwnerAddress
ASTELLAS PHARMA INCTOKYO
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEKUMAMOTO 860-8568 JAPAN

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fujita, Hirotada Tokyo, JP 4 3
Higuchi, Hirofumi Kumamoto, JP 69 634
Ishikawa, Daisuke Kumamoto, JP 109 318
Nakashima, Toshihiro Kumamoto, JP 44 605
Sakai, Fumihiko Tokyo, JP 14 46
Uehara, Kenji Kumamoto, JP 20 447
Yamamoto, Nobuchika Tokyo, JP 8 61

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