MESP1 AS A MASTER REGULATOR OF MULTIPOTENT CARDIOVASCULAR PROGENITOR SPECIFICATION AND USES THEREOF
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United States of America Patent
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Issued Date -
Dec 30, 2010
app pub date -
Jun 30, 2009
filing date -
Jun 30, 2009
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Abstract
A method for differentiating or promoting or inducing differentiation of stem cells into pluripotent cardiovascular progenitors (MCPs) by transiently inducing the expression of a single gene, namely Mesp1, is disclosed. Cells obtained by the method and their uses in research and clinical settings are also disclosed. Using genome wide transcriptional analysis, the inventors found that Mesp1 rapidly activates and represses a discrete set of genes, which form potential new targets for both therapy and for the identification of MCPs. Insights into the molecular mechanisms underlying the earliest step of cardiovascular specification and potential methods for dramatically increasing the number of cardiovascular cells for cellular therapy in humans are provided.
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