MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS
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United States of America Patent
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Issued Date -
Dec 23, 2010
app pub date -
Jan 4, 2008
filing date -
Jan 8, 2007
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Abandoned
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Abstract
The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The compounds find utility as antiviral agents directed at hepatitis C. The invention further provides methods of employing such inhibitors, alone or in combination with other therapeutic agents, to treat hepatitis C infection in a subject in need of such treatment.
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