B CELL TOLERANCE INDUCTION
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United States of America Patent
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Issued Date -
Dec 23, 2010
app pub date -
Oct 8, 2008
filing date -
Oct 8, 2007
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Abstract
The present invention relates to the induction of immune tolerance, by a novel method of induction of IL-10 production in B cells, whereby said B cells can be loaded with antigen before, during or after the induction of the IL-10 production. More specifically, the invention relates to the transduction of the B cell with a retroviral vector encoding an antigen, whereby the retroviral envelop induces IL-10 production in the B cell by activation the TLR2 receptor, in combination with its viral receptor.
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