ENZYME AND RECEPTOR MODULATION
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United States of America Patent
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Issued Date -
Dec 16, 2010
app pub date -
Feb 27, 2009
filing date -
Feb 29, 2008
priority date (Note) -
Abandoned
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Abstract
Covalent conjugates of an α,α-disubstituted glycine ester and a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid and the α,α-disubstituted glycine ester is conjugated to the modulator at a position remote from the binding interface between the inhibitor and the target enzyme or receptor pass into cells and the active acid hydrolysis product accumulates within the cells.
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