SUBSTITUTED ARYL-FUSED SPIROCYCLIC AMINES
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United States of America Patent
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Issued Date -
Dec 16, 2010
app pub date -
Sep 19, 2008
filing date -
Sep 21, 2007
priority date (Note) -
Abandoned
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Abstract
Substituted Aryl-fused Spirocyclic Amines of the formula (I): are provided, as are methods for their preparation and use. Such compounds may generally be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and therapeutic methods are provided, as are methods for using such ligands for detecting histamine H3 receptors (e.g., receptor localization studies).
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