METHOD FOR DIAGNOSING BLADDER CANCER BY ANALYZING DNA METHYLATION PROFILES IN URINE SEDIMENTS AND ITS KIT
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United States of America Patent
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Issued Date -
Dec 16, 2010
app pub date -
Jul 23, 2008
filing date -
Jul 23, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention provides a method for detecting bladder cancer in a subject, comprising the following steps: (a) providing urine sediment sample from said subject; (b) determining methylation pattern of a given sequence within the promoter CpG islands of one or more genes (known as “gene” infra) in the samples; (c) comparing the methylation pattern from said subject with that from normal subject, wherein the hypermethylation of one or more of genes indicates that said subject is suffering from bladder cancer. The present invention also provides a kit for diagnosing bladder cancer.
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