MODIFIED 2' AND 3' NUCLEOSIDE PRODRUGS FOR TREATING FLAVIVIRIDAE INFECTIONS

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United States of America Patent

APP PUB NO 20100316594A1
SERIAL NO

12131868

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Abstract

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2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

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Patent Owner(s)

Patent OwnerAddress
IDENIX PHARMACEUTICALS INC320 BENT STREET FLOOR 4 CAMBRIDGE MA 02141
THE CENTRE NATIONAL DEL LA RECHERCHE SCIENTIFICQUECAMPUS GERARD MEGIE RUE MICHEL - ANGE PARIS
UNIVERSITY OF CAGLIARIVIA UNIVERSITA 40 CAGLIARI 09124
L'UNIVERSITE MONTPELLIER II5 BD HENRI IV CS 19044 MONTPELLIER CEDEX 2 34967

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gosselin, Gilles Monpellier, FR 98 3486
LaColla, Paolo Cagliari, IT 17 523
Sommadossi, Jean-Pierre Cambridge, US 125 4472
Storer, Richard Kent, GB 78 2192

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