AQUEOUS BASED PHARMACEUTICAL FORMULATIONS OF WATER-SOLUABLE PRODRUGS OF PROPOFOL
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United States of America Patent
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Issued Date -
Dec 9, 2010
app pub date -
Sep 20, 2007
filing date -
Oct 5, 2006
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Abandoned
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Abstract
The present invention is directed to aqueous based formulations of water-soluble prodrugs of propofol. The formulations comprise in aqueous medium an effective amount of the water-soluble prodrug of propofol in the absence of an antioxidant. The formulations are particularly useful as intravenous injections. The formulations preferably are buffered to a pH suitable for minimizing degradation of the prodrug during storage. The formulations can be prepared without the use of harmful co-solvents or surfactants and are stable at room temperature over extended periods of time.
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