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Abstract

The combination of vasopressin V2 receptor antagonists and vasopressin receptor agonists (selective or non-selective) is described, including pharmaceutical compositions, including kits, for administering, and methods and uses of such a combination, e.g. for treatment of critical care diseases and conditions requiring control of arterial blood pressure or for treatment of hypotension. Also described is the use of a combination of a vasopressin V2 receptor antagonist with a vasopressin receptor agonist for the manufacture of a medicament for treatment of critical care conditions requiring control of arterial blood pressure, vascular leak and/or vasodilation, methods for treatment of a critical care condition in a mammal needing control of arterial blood pressure, vascular leak and/or vasodilation, the method comprising administering to the mammal a therapeutically effective amount of a vasopressin V2 receptor antagonist and administering to the mammal a therapeutically effective amount of a vasopressin receptor agonist, and a kit comprising a therapeutically effective amount of one or more vasopressin V2 receptor antagonists in a pharmaceutically acceptable composition and a therapeutically effective amount one or more vasopressin receptor agonists in a pharmaceutically acceptable composition.

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First Claim