POLYNUCLEOTIDE SEQUENCE FOR THE INHIBITION OF PHOSPHOLAMBAN SYNTHESIS
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United States of America Patent
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Issued Date -
Dec 9, 2010
app pub date -
Dec 28, 2007
filing date -
Dec 29, 2006
priority date (Note) -
Abandoned
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Abstract
A DNA polynucleotide sequence is disclosed that comprises a transcribed sequence, and a promoter sequence. Transcription of the transcribed sequence by an RNA polymerase in a cell renders an RNA a transcript capable of forming a partially self-complementary hairpin structure which can be processed by the cell to an siRNA product that can degrade phospholamban mRNA in such cell. The promoter is a drug inducible conditional promoter or a cardiomyocyte cell-specific promoter or both, operably linked to the transcribed sequence. The promoter is operable by an RNA polymerase naturally occurring in a mammalian cell.
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