SYSTEM AND METHOD FOR PRODUCING SYNTHETIC MICROORGANISMS CAPABLE OF TRANSLATING PROTEINS CONTAINING NON-STANDARD AMINO ACIDS
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United States of America Patent
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Issued Date -
Nov 25, 2010
app pub date -
Oct 8, 2008
filing date -
Oct 8, 2007
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Abstract
The disclosed invention relates to the generation of host cells containing rare codons and/or absent tRNAs, and the use of orthogonal tRNA systems that can insert a non-standard amino acid into a growing peptide chain. This invention combined with the capacity to synthesize whole genomes has important implications in synthetic biology, as it allows the rewriting of the genetic code of existing or newly designed organisms.
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