Compositions and Methods Related to Fructosamine-3-Kinase Inhibitors

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United States of America Patent

APP PUB NO 20100297046A1
SERIAL NO

12294182

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Abstract

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The invention relates to compounds and methods for inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin, by way of fructosamine-3-kinase inhibition, thereby treating or prevention various diseases, disorders or conditions. Additionally, the invention relates to treatment of various diseases, disorders or conditions associated with or mediated by oxidative stress since 3DG induces ROS and AGEs, which are associated with the inflammatory response caused by oxidative stress.

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Patent Owner(s)

Patent OwnerAddress
DYNAMIS THERAPEUTICS INCWYNDMOOR PLAZA 8360 OLD YORK ROAD ELKINS PARK PA 19027-1598

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kappler, Francis Philadelphia, US 16 268
Schwartz, Michael Palmyra, US 64 1551
Su, Bangying Elkins Park, US 6 62

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