SCREENING METHOD FOR AGENTS SUITABLE FOR THERAPY OF ALZHEIMER'S DISEASE
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United States of America Patent
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Issued Date -
Nov 18, 2010
app pub date -
Nov 26, 2008
filing date -
Nov 27, 2007
priority date (Note) -
Abandoned
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Abstract
Described is a method of screening for therapeutic agents for the prophylaxis and therapy of Alzheimer's disease (AD), wherein agents that (i) do not interfere with the biological activity of gamma-secretase, (ii) do not exhibit cytotoxicity, (iii) lead to reduced amounts of Abeta42 and (iv) are capable of binding to an APP-GxxxG motif thereby weakening or inhibiting dimerization of the APP transmembrane sequence are suitable for prophylaxis or treatment of AD.
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