Methods of Detecting Target Nucleic Acids
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United States of America Patent
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app pub date -
Mar 12, 2007
filing date -
Mar 12, 2006
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Abstract
The present disclosure relates to methods of identifying target nucleic acids by using coded molecules and its analysis by translocation through a nanopore. Generally, coded molecules are subject to a target polynucleotide dependent modification. The modified coded molecule is detected by isolating the modified coded molecules from the unmodified coded molecules prior to analysis through the nanopore or by detecting a change in the signal pattern of the coded molecule when analyzed through the nanopore.
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