COMPOSITIONS AFFECTING HYALURONIC ACID MEDIATED ACTIVITY

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United States of America Patent

APP PUB NO 20100290989A1
SERIAL NO

12682774

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Abstract

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Compositions comprising hyaluronic acid (HA) or agents that interfere with HA binding of HA receptors and methods of using the same are provided. For example, there is provided a composition comprising HA oligomers ranging in size from 10-mer to 80-mer and use of the same for promoting migration, growth or survival of wild-type or transformed/cancerous cells. There is also provided a composition comprising an agent that interferes with binding between an HA oligomer of a size of about 10-mer to about 80-mer and an HA receptor. Such compositions may be useful for therapeutic, diagnostic or imaging applications. Examples of therapeutic use are wound repair or cancer treatment.

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Patent Owner(s)

Patent OwnerAddress
REGENTS OF THE UNIVERSITY OF MINNESOTA600 MCNAMARA ALUMNI CENTER 200 OAK STREET SE MINNEAPOLIS MN 55455-2020

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Luyt, Leonard G London, CA 7 7
McCarthy, Jim St. Paul, US 3 28
Tolg, Cornelia London, CA 1 6
Turley, Eva London, CA 5 9

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