TOPICAL COMPOSITIONS FOR DELIVERY OF PROTEINS AND PEPTIDES
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United States of America Patent
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Issued Date -
Nov 4, 2010
app pub date -
Dec 19, 2008
filing date -
Jan 2, 2008
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Abandoned
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Abstract
Aspects of this invention relate to compositions and methods for the stabilization, storage, and delivery of biologically active agents, in particular peptides and nucleic acids. Particularly preferred embodiments include compositions that comprise a recombinant naturally occurring human hepatocyte growth factor (HGF), such as dHGF, a five amino acid truncated HGF variant, and at least one monoglyceride that remains in crystalline form at body temperature. Optionally, a gelling agent such as, hydroxyethylcellulose, and/or an antipathogenic compound (e.g., bupivacaine) can be included in the composition. Methods of use of these compositions to improve, ameliorate, or treat skin conditions are also embodiments.
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