COMPOUNDS FOR FLUORESCENCE IMAGING
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United States of America Patent
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Issued Date -
Nov 4, 2010
app pub date -
Dec 21, 2007
filing date -
Dec 21, 2006
priority date (Note) -
Abandoned
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Abstract
Methods and compositions involving enzyme-activatable fluorophore polymer imaging agents for photodetection of specific tissues and/or human diseases and disorders are provided. In certain embodiments, the imaging agent comprises a hydrophilic polymer backbone (e.g., poly(L)lysine), a hydrophobic fluorophore, and a hydrophilic solubilizing agent. The solubilizing agent may comprise a quarternary ammonium group (e.g., a 1-methylnicotinic group) to enhance self-quenching of the fluorophore. Various methods for the generation and purification of imaging agents are also provided, including methods involving solid phase probe extraction or ion exchange purification.
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