Method of Synthesizing 6,7-Substituted 4-Anilino Quinazoline
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United States of America Patent
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Issued Date -
Oct 21, 2010
app pub date -
May 13, 2009
filing date -
Apr 16, 2009
priority date (Note) -
Abandoned
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Abstract
A method of synthesizing 6,7-substituted 4-anilino quinazoline employs 3,4-substituted benzoic acid as an initial reactant, and the 6,7-substituted 4-anilino quinazoline is obtained by an esterifying step, a nitrating step, a reducing step, a cyclizing step, and an one-pot reaction. In the above method, the initial reactant has low cost and yield. of the 6,7-substituted 4-anilino quinazoline is high, therefore, production cost can be reduced effectively, and competitive power of the product of the 6,7-substituted 4-anilino quinazoline can be improved.
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