SMAC mimetic compounds as apoptosis inducers
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United States of America Patent
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Dec 17, 2013
Grant Date -
Oct 21, 2010
app pub date -
Nov 5, 2008
filing date -
Nov 9, 2007
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Abstract
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
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