TREATMENT AND PREVENTION OF ISCHEMIC INJURY USING ACTIVATED PROTEIN C
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United States of America Patent
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Issued Date -
Oct 21, 2010
app pub date -
Apr 15, 2009
filing date -
Apr 15, 2009
priority date (Note) -
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Abstract
Methods and compositions are provided for treating or preventing ischemic injury in a tissue flap in order to reduce the incidence of flap necrosis. Some compositions comprise one or more of an activated protein C (APC), a functional fragment of an APC, an APC mimetic compound, and a derivative of APC. Some methods comprise administering to a subject a therapeutically effective amount of an agent comprising one or more of an activated protein C (APC), a functional fragment of an APC, an APC mimetic compound, and a derivative of APC.
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