STABLE ANTIBODY FORMULATIONS
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United States of America Patent
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Issued Date -
Oct 14, 2010
app pub date -
Mar 20, 2008
filing date -
Mar 22, 2007
priority date (Note) -
Abandoned
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Abstract
The present invention provides formulations and methods for the stabilization of antibodies. In one embodiment, the invention provides the stable solution formulation of an IgG1 antibody that specifically binds to insulin-like growth factor-I receptor. In another embodiment, the invention provides methods of stabilization of IgG1 antibody that specifically binds to insulin-like growth factor-I receptor comprising lyophilizing an aqueous formulation of the antibody. The formulations can be lyophilized to stabilize the antibodies during processing and storage, and then the formulations can be reconstituted for pharmaceutical administration.
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