Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
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United States of America Patent
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May 8, 2012
Grant Date -
Oct 14, 2010
app pub date -
Jan 19, 2006
filing date -
Jan 19, 2006
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Abstract
There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.
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