Methods for purifying nucleic acids

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United States of America Patent

PATENT NO 8680261
SERIAL NO

12796961

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Abstract

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Methods are provided for producing highly purified compositions of nucleic acids by using a highly streamlined and readily automated process. The methods use static mixers for lysing cells and precipitating debris, following by centrifugation and ion exchange chromatography. The process may include a purification step using tangential flow ultrafiltration. A scaleable process for producing pharmaceutical grade plasmid DNA, useful for gene therapy, is provided.

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Patent Owner(s)

Patent OwnerAddress
URIGEN PHARMACEUTICALS INC675 U S HIGHWAY ONE SUITE B206 NORTH BRUNSWICK NJ 08902

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bridenbaugh, Robert Milbrae, US 3 106
Bussey, Lee B San Mateo, US 8 62
Dang, Warren Alameda, US 4 156

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